SpamAssassin is a mail filter in cPanel which helps to reduce the amount of spam sent to your email accounts. By utilising a set of 'rules' SpamAssassin will remove junk mail from your account automatically or mark it as SPAM for you to review.
To enable SpamAssassin login to your cPanel control panel and click "SpamAssassin" which you will find under the "Mail" group of icons. From there you can choose to enable or disable the SpamAssassin and set the options it uses for checking email for spam.